Description
Mucosal vascular addressin cell adhesion molecule 1 (MAdCAM-1) is a multifunctional type l transmembrane adhesion molecule that is expressed selectively at venular sites of lymphocyte extravasation into mucosal lymphoid tissues and lamina propria, where it directs local lymphocyte trafficking. MAdCAM-1 is involved in the normal recirculation of lymphocytes between the blood and the gastrointestinal tract. MAdCAM-1 may be a relevant tissue-specific therapeutic target for the modulation of inflammatory bowel disease activity