Description
IL-17C is a member of the IL-17 family, which is comprised of six proteins (IL-17A through IL-17F). IL-17 proteins are pro-inflammatory cytokines that induce local cytokine production and are involved in the re-gulation of immune functions. IL-17C has been reported to stimulate the release of TNF-alpha and IL-1β from the monocytic cell line THP-1. IL-17C shares 15% to 30% amino acid sequence identity with the other IL-17 family members. Mouse and human IL-17C share 83% amino acid sequence identity. Mouse IL-17C cDNA encodes a 194 amino acid protein with a putative 14 amino acid signal peptide. The recombinant mouse IL-17C is a disulfide-linked homodimer composed of a 20.2 kDa monomeric subunit