Description
Fibroblast growth factor receptor 4 (FGFR4) is a member of a family of transmembrane receptors with ligand-induced tyrosine kinase activity that is expressed at significant levels in almost all human prostate cancers, and expression of its ligands is ubiquitous. FGFR4 plays essential roles in systemic lipid and glucose homeostasis. FGFR4 may be an important regulator of osteogenesis with involvement in preosteoblast proliferation and differentiation as well as osteoblast functioning during intramembranous ossification. FGFR-4 signaling and receptor turnover are important potential therapeutic targets in prostate cancer