Description
Neurotrophic tyrosine kinase receptor type 3, also known as NT-3 growth factor receptor, TrkC tyrosine kinase, TrkC and NTRK3, is a single-pass type I membrane protein. NTRK3 belongs to the protein kinase superfamily and insulin receptor subfamily. Mouse NTRK3 is a 825 amino acid (aa) protein and is widely expressed but mainly in nervous tissue. It contains two Ig-like C2-type (immunoglobulin-like) domains, one LRR (leucine-rich) repeats and one protein kinase domain. NTRK3 is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway