Description
VDAC forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel allows diffusion of small hydrophilic molecules; it adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has weak anion selectivity whereas the closed state is cation-selective. rh-VDAC is expressed inE. coli.