Universal Type I Interferon 11200-1 from PBL Assay Science

Product Specs
ItemUniversal Type I Interferon
CompanyPBL Assay Science
Price $365.00Supplier Page View Company Product Page
Catalog Number11200-1
Purity>95%
SpeciesHuman
ActivityActivity: 1.0 x 10⁸ u/mg
Source/Expression SystemE.coli
FormatPBS + 0.1% BSA
Molecule NameIFN-Alpha A/D hybrid
Size1 x 105 Units
Gene NameNotch
TypeProtein
Molecular Weight19.4 kDa

Additional Product Information

Protein/Peptide:
IFN, Universal Type I (IFN Alpha A/D (BglII))

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PBL Assay Science

131 Ethel Road West. Suite 6

Piscataway, New Jersey

United States

Phone: 1-877-725-8881
1-732-777-9123
1-732-777-9141

Company Profile

Website: www.pblassaysci.com

(1) SARS-CoV-2 Nsp14 binds Tollip and activates pro-inflammatory pathways while downregulating interferon-α and interferon-γ receptorsmBioAugust 13, 2025Thakur N, Chakraborty P, Tufariello JM, Basler CF.(PeproTech 300-02-100ug), and Universal Type I IFN (Human IFN-Alpha Hybrid Protein) (PBL Assay Science 11200-1). SARS-CoV-2 isolate USA-WA1/2020 was kindly provided by the García-Sastre laboratory at Icahn School

(2) Genetic ancestry shapes dengue virus infection in human skin explantsProceedings of the National Academy of Sciences of the United States of AmericaJuly 15, 2025Castanha PMS, Martí MM, Duangkhae P, Taddonio JM, Cooper KL, Wallace M, Kettenburg G, Erdos G, Chavva H, Alex A, et al.individual arrays were formulated to contain 100 IU of recombinant human IFN-α (PBL Assay Science, 11200-1), 50 ng of recombinant human IL-1β (R&D Systems, 201-LB-005-CF), 20 μg of neutralizing antibody to human

(3) Bat organoids reveal antiviral responses at epithelial surfacesNature immunologyJune 1, 2025Kellner MJ, Monteil VM, Zelger P, Pei G, Jiao J, Onji M, Nayak K, Zilbauer M, Balkema-Buschmann A, Dorhoi A, et al.induction of ISGs (IFIT1, OAS1, RTP4) using RT–qPCR, 8 h after stimulation. Universal IFNα2 (cat. no. 11200-1, PBL Assay Science) at 1,000 U ml−1 was used as the positive control; unmodified Lenti-X culture supernatant

(4) Interferon-induced PARP14-mediated ADP-ribosylation in p62 bodies requires the ubiquitin-proteasome systemThe EMBO JournalApril 7, 2025Rameez Raja, Banhi Biswas, Rachy Abraham, Yiran Wang, Che-Yuan Chang, Ivo A Hendriks, Sara C Buch-Larsen, Hongrui Liu, Xingyi Yang, Chenyao Wang, et al.PROTEOSTAT Aggresome Detection kit,Enzo Life Sciences,ENZ-51035,,, Puromycin,Invivogen,ant-pr-1,,, Human IFNα,PBL Assay Science,11200-1,,, Human IFN Beta,PBL Assay Science,11415-1,,, Human IFNγ,Sigma-Aldrich,SRP3058,,, Lipofectamine

(5) VAX014 Activates Tumor-Intrinsic STING and RIG-I to Promote the Development of Antitumor ImmunityMolecular Cancer TherapeuticsApril 2, 2025Kinsey L. Nelson, Katherine A. Reil, Shingo Tsuji, Amanda M. Parikh, Mikella Robinson, Carrie D. House, Kathleen L. McGuire, Matthew J. Giacalonefor 4 hours prior to the addition of 1.0 × 106 U/mL universal type I IFN-α (PBL Assay Science, Cat# 112001). After 24 hours of incubation with universal type I IFN, VAX014 rBMCs were added at MOI titrations

(6) Examining the feasibility of replacing ORF3a with fluorescent genes to construct SARS-CoV-2 reporter virusesJ Gen VirolFebruary 12, 2025Isobel Webb, Maximillian Erdmann, Rachel Milligan, Megan Savage, David A. Matthews, Andrew D. Davidsonpre-treated with titrated amounts of type I IFN [IFN-α; universal type I IFN (human IFN-alpha hybrid protein, 11200-1-PBL, Stratech, Piscataway, NJ, USA] for 18 h. Cells were washed once with infection media to remove

(7) SARS-CoV-2 Nsp14 binds Tollip and activates pro-inflammatory pathways while downregulating interferon-α and interferon-γ receptorsbioRxivDecember 17, 2024Naveen Thakur, Poushali Chakraborty, JoAnn M. Tufariello, Christopher F. Basler(PeproTech 300–02-100ug) and Universal™ Type I IFN (Human IFN-Alpha Hybrid Protein) (PBL Assay Science 11200–1). SARS-CoV-2 isolate USA-WA1/2020 was kindly provided by the García-Sastre laboratory at Icahn School

(8) Thioredoxin is a metabolic rheostat controlling regulatory B cellsNature ImmunologyMay 1, 2024Hannah F. Bradford, Thomas C. R. McDonnell, Alexander Stewart, Andrew Skelton, Joseph Ng, Zara Baig, Franca Fraternali, Deborah Dunn-Walters, David A. Isenberg, Adnan R. Khan, et al.Sigma-Aldrich). Where applicable, cells were stimulated with recombinant human IFNα (1,000 U ml−1; PBL, 11200-1), mega-CD40L (1 μg ml−1; Enzo, cat. no. ALZ-522-110-C010), anti-IgM/G/A (10 μg ml−1; Sigma-Aldrich,

(9) Type I interferon regulates interleukin-1beta and IL-18 production and secretion in human macrophagesLife Sci AllianceMarch 25, 2024Rodrigo Díaz-Pino, Gillian I Rice, Diego San Felipe, Tamar Pepanashvili, Paul R Kasher, Tracy A Briggs, Gloria López-CastejónIFN Beta (Beta 1a, Mammalian Expressed) (11415-1) and Human IFN Alpha Hybrid (Universal Type I IFN) (11200-1) were obtained from PBL Assay Science. Phosphatase inhibitor cocktail (78420) was sourced from Thermo Fisher Scientific

(10) Memory T cells possess an innate-like function in local protection from mucosal infectionThe Journal of clinical investigationMay 15, 2023Arkatkar T, Davé V, Cruz Talavera I, Graham JB, Swarts JL, Hughes SM, Bell TA, Hock P, Farrington J, Shaw GD, et al.ng/mL (MBL International, catalog B003-5, lot 091); human IFN-α, 500 U (PBL Assay Science, catalog 11200-1, lot 7155); human IFN-β, 500 U (PBL Assay Science, catalog 11415-1, lot 7349). GolgiPlug (BD Biosciences)

(11) ATR-mediated DNA damage responses underlie aberrant B cell activity in systemic lupus erythematosusScience advancesOctober 28, 2022Manolakou T, Nikolopoulos D, Gkikas D, Filia A, Samiotaki M, Stamatakis G, Fanouriakis A, Politis P, Banos A, Alissafi T, et al.sCD40L/CD154 (1 μg/ml; catalog no. 11343345, ImmunoTools). To mimic DDR in SLE B cells, IFN-α (catalog no. 11200-1, PBL Assay Science) was added to cells at 850 U/ml. For chemical ATR inhibition, berzosertib (i.e.,

(12) Potent Antiviral Activities of Type I Interferons to SARS-CoV-2 InfectionbioRxivSeptember 25, 2022Emily Mantlo, Natalya Bukreyeva, Junki Maruyama, Slobodan Paessler, Cheng Huanghuman IFN-β1a (mammalian, cat# 11415, PBL) and IFN-α (Universal Type I alpha A/D (Bg III), PBL, cat# 11200–1) at different concentrations for 16 h. Cells were then infected with SARS-CoV-2 at an MOI of 0.01 TCID50/cell.

(13) 2'-O-Methylation of the second transcribed nucleotide within the mRNA 5' cap impacts the protein production level in a cell-specific manner and contributes to RNA immune evasionNucleic acids researchSeptember 9, 2022Drazkowska K, Tomecki R, Warminski M, Baran N, Cysewski D, Depaix A, Kasprzyk R, Kowalska J, Jemielity J, Sikorski PJ.conditions To stress the cells, incubation in medium with addition of Universal Type I Interferon (IFNα) (11200-1, PBL Assay Science) was performed. For quantitative reverse transcription—PCR (RT–qPCR) assessment of

(14) Epstein-Barr virus tegument protein BGLF2 in exosomes released from virus-producing cells facilitates de novo infectionCell communication and signaling : CCSJune 21, 2022Sato Y, Yaguchi M, Okuno Y, Ishimaru H, Sagou K, Ozaki S, Suzuki T, Inagaki T, Umeda M, Watanabe T, et al.BioScience, Irvine, CA, USA) was used at a concentration of 100 nM. Recombinant human type I IFN alpha (Cat# 11200-1) and IFN beta (Cat# 11415-1) were purchased from PBL Assay Science (Piscataway, NJ, USA). For inhibition

(15) EMT alterations in the solute carrier landscape uncover SLC22A10/A15 imposed vulnerabilities in pancreatic canceriScienceMay 20, 2022Nayak D, Weadick B, Persaud AK, Raj R, Shakya R, Li J, Campbell MJ, Govindarajan R.04906837001 PMSF,Millipore-Sigma,Cat# 7110 Crystal Violet,Sigma Aldrich,Cat# C0775 Universal Type I Interferon,PBL assay science,Cat# 11200-1 Recombinant Human IFN-γ,R&D systems,Cat# 285-IF-100 L-Buthionine-sulfoximine,Sigma-Aldrich,Cat# B2515 Gemcitabine hydrochloride

(16) African swine fever virus ubiquitin-conjugating enzyme pI215L inhibits IFN-I signaling pathway through STAT2 degradationFrontiers in microbiologyJanuary 1, 2022Riera E, García-Belmonte R, Madrid R, Pérez-Núñez D, Revilla Y.assays, cells were treated with universal type I IFN at the indicated concentrations (PBL; catalog no 11200–1). Cytosine arabinoside (AraC) was employed at a concentration of 40 mg/mL during infection. Plasmids

(17) Selection and stability validation of reference gene candidates for transcriptional analysis in Rousettus aegyptiacusScientific ReportsDecember 1, 2021Virginia Friedrichs, Anne Balkema-Buschmann, Anca Dorhoi, Gang Peifibroblasts (#C0045C, Thermo Fisher Scientific) were incubated with 1000U/ml universal IFN-I (uIFN) (#11200-1, PBL Assay Science) for 1 h, 2 h and 4 h at either 35 °C, 37 °C or 40 °C, respectively. RNA extraction

(18) MiRNA post-transcriptional modification dynamics in T cell activationiScienceJune 25, 2021Rodríguez-Galán A, Dosil SG, Gómez MJ, Fernández-Delgado I, Fernández-Messina L, Sánchez-Cabo F, Sánchez-Madrid F.STEMCELL Technologies, 10971) or IFN I (1:1000, Human IFN Alpha Hybrid (Universal Type I IFN); PBL ASSAY SCIENCE, 11200-1). RNA isolation, library preparation and NGS Three independent experiments, with resting CD4+ T cells

(19) Ubiquitin-Specific Protease 6 Functions as a Tumor Suppressor in Ewing Sarcoma through Immune ActivationCancer researchApril 15, 2021Henrich IC, Jain K, Young R, Quick L, Lindsay JM, Park DH, Oliveira AM, Blobel GA, Chou MM.Jak Inhibitor I (#420099) and PS-1145 (P6624), Sigma. IFN α and β were from PBL Assay Science (#11410-2 and #11200-1), and IFNγ from PeproTech (#300-02). Lipofectamine 2000 was from Life Technologies. Flow antibodies/reagents

(20) STING controls nociception via type I interferon signalling in sensory neuronsNatureMarch 11, 2021Christopher R. Donnelly et al.12410-1), recombinant universal type-I interferon (various concentrations, as indicated; PBL Assay Science, 11200-1), H-151 (10 nmol, i.t.; Cayman Chemical, #25857), C-176 (10 nmol, i.t.; Cayman Chemical, #25859), PF-06700841

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Universal Type I Interferon from PBL Assay Science

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Universal Type I Interferon from PBL Assay Science

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