GDF-15 Protein 957-GD-025 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemGDF-15 Protein
CompanyR&D Systems, a Bio-Techne Brand
Price $428.00Supplier Page View Company Product Page
Catalog Number957-GD-025
SpeciesHuman
Molecule NameGDF-15
Size25 ug
Source/Expression SystemCHO-derived Recombinant Human GDF-15 (CHO-expressed) Protein
NCBI Full Gene Namegrowth differentiation factor 15
NCBI Gene AliasesGDF-15, NAG-1, MIC1, PTGFB, MIC-1, PDF, PLAB
FormatLyophilized from a 0.2 µm filtered solution in Acetonitrile and TFA with BSA as a carrier protein
Purity>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining
ApplicationsBioactivity not tested
Conjugate/TagUnconjugated
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution

Specifications/Features

Available conjugates: Sizes Available: 25 ug

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) A PTER-dependent pathway of taurine metabolism linked to energy balancebioRxiv : the preprint server for biologyMarch 22, 2024Wei W, Lyu X, Markhard AL, Fu S, Mardjuki RE, Cavanagh PE, Zeng X, Rajniak J, Lu N, Xiao S, et al.

(2) Lac-Phe mediates the anti-obesity effect of metforminbioRxiv : the preprint server for biologyNovember 4, 2023Xiao S, Li VL, Lyu X, Chen X, Wei W, Abbasi F, Knowles JW, Deng S, Tiwari G, Shi X, et al.

(3) Identification of GDF15 peptide fragments inhibiting GFRAL receptor signalingPeptidesOctober 1, 2023Alexopoulou F, Buch-Månson N, Pedersen SL, Vrang N, Fink LN, Strømgaard K.

(4) Extending the dynamic range of biomarker quantification through molecular equalizationNature communicationsJuly 13, 2023Newman SS, Wilson BD, Mamerow D, Wollant BC, Nyein H, Rosenberg-Hasson Y, Maecker HT, Eisenstein M, Soh HT.

(5) A brainstem circuit for nausea suppressionCell reportsJune 14, 2022Zhang C, Vincelette LK, Reimann F, Liberles SD.

(6) Non-canonical open reading frames encode functional proteins essential for cancer cell survivalNature BiotechnologyJune 1, 2021John R. Prensner et al.shown. Recombinant GDF15 experiments: Recombinant human GDF15 (R&D Systems, Minneapolis, MN, catalogue number 957-GD-025) was resuspended in water at 10ug/uL. Knockout with sgGREP1 #2 or controls in ZR-75–1 was performed

(7) Development of a novel and rapid measurement system for growth differentiation factor-15, progranulin, and osteopontin in uterine sarcomaEndocrine journalJanuary 28, 2020Maeno M, Mizutani T, Tsuyoshi H, Yamada S, Ishikane S, Kawabe S, Nishimura K, Yamada M, Miyamoto K, Yoshida Y.

(8) Circulating levels of GDF15 in patients with myalgic encephalomyelitis/chronic fatigue syndromeJournal of translational medicineDecember 4, 2019Melvin A, Lacerda E, Dockrell HM, O'Rahilly S, Nacul L.

(9) Inhibition of Breast Cancer Cell Invasion by Ras Suppressor-1 (RSU-1) Silencing Is Reversed by Growth Differentiation Factor-15 (GDF-15)International journal of molecular sciencesJanuary 4, 2019Gkretsi V, Louca M, Stylianou A, Minadakis G, Spyrou GM, Stylianopoulos T.

(10) Reduced oxidative capacity in macrophages results in systemic insulin resistanceNature communicationsApril 19, 2018Jung SB, Choi MJ, Ryu D, Yi HS, Lee SE, Chang JY, Chung HK, Kim YK, Kang SG, Lee JH, et al.

(11) An autocrine/paracrine circuit of growth differentiation factor (GDF) 15 has a role for maintenance of breast cancer stem-like cellsOncotargetApril 11, 2017Sasahara A, Tominaga K, Nishimura T, Yano M, Kiyokawa E, Noguchi M, Noguchi M, Kanauchi H, Ogawa T, Minato H, et al.

(12) GDF15 contributes to radioresistance and cancer stemness of head and neck cancer by regulating cellular reactive oxygen species via a SMAD-associated signaling pathwayOncotargetJanuary 3, 2017Li YL, Chang JT, Lee LY, Fan KH, Lu YC, Li YC, Chiang CH, You GR, Chen HY, Cheng AJ.

(13) TGF-β contamination of purified recombinant GDF15PloS oneJanuary 1, 2017Olsen OE, Skjærvik A, Størdal BF, Sundan A, Holien T.

(14) Growth Differentiation Factor-15-Induced Contractile Activity and Extracellular Matrix Production in Human Trabecular Meshwork CellsInvestigative ophthalmology & visual scienceDecember 1, 2016Muralidharan AR, Maddala R, Skiba NP, Rao PV.

(15) GDF15/MIC1 and MMP9 Cerebrospinal Fluid Levels in Parkinson's Disease and Lewy Body DementiaPloS oneJanuary 1, 2016Maetzler W, Deleersnijder W, Hanssens V, Bernard A, Brockmann K, Marquetand J, Wurster I, Rattay TW, Roncoroni L, Schaeffer E, et al.

(16) Macrophage inhibitory cytokine 1 biomarker serum immunoassay in combination with PSA is a more specific diagnostic tool for detection of prostate cancerPloS oneJanuary 1, 2015Li J, Veltri RW, Yuan Z, Christudass CS, Mandecki W.

(17) Marked improvement of cytotoxic effects induced by docetaxel on highly metastatic and androgen-independent prostate cancer cells by downregulating macrophage inhibitory cytokine-1British journal of cancerMarch 19, 2013Mimeault M, Johansson SL, Batra SK.

(18) GDF-15 prevents platelet integrin activation and thrombus formationJournal of thrombosis and haemostasis : JTHFebruary 1, 2013Rossaint J, Vestweber D, Zarbock A.

(19) Growth differentiation factor-15 suppresses maturation and function of dendritic cells and inhibits tumor-specific immune responsePloS oneJanuary 1, 2013Zhou Z, Li W, Song Y, Wang L, Zhang K, Yang J, Zhang W, Su H, Zhang Y.

(20) Soluble endoglin specifically binds bone morphogenetic proteins 9 and 10 via its orphan domain, inhibits blood vessel formation, and suppresses tumor growthThe Journal of biological chemistryAugust 26, 2011Castonguay R, Werner ED, Matthews RG, Presman E, Mulivor AW, Solban N, Sako D, Pearsall RS, Underwood KW, Seehra J, et al.

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GDF-15 Protein

GDF-15 Protein

GDF-15 Protein from R&D Systems, a Bio-Techne Brand

Specifications/Features

R&D Systems, a Bio-Techne Brand

Citations (30)

Reviews

GDF-15 Protein from R&D Systems, a Bio-Techne Brand

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