Description
Purified recombinant Human IL31 protein
Human IL31 is a T-cell derived cytokine that shares several structural and functional characteristics with IL6, Oncostatin M, LIF, and Cardiotrophin-1. It signals through a receptor complex comprised of GPL (GP130-like, IL31RA) and OSMR (Oncostatin M receptor). GPL/OSMR signaling is a strong activator of STAT3 and STAT5, and can also activate STAT1, Jak1, and Jak2 signaling pathways. IL31 regulated immune responses have been implicated in skin physiology and inflammatory skin diseases