Description
CIB, KIP(Kinase interacting protein), SIP2-28 (SNK interacting protein2-28), CALMYRIN Description: CIB1 (Calcium and integrin binding 1) is regulatory protein with 50% homology to calmodulin and calcineurin B, that encodes a member of the calcium-binding protein family. The specific function of this protein has not yet been determined; however this protein is known to interact with DNA-dependent protein kinase and may play a role in kinase-phosphatase regulation of DNA end joining. Also CIB1 is widely expressed and binds to a number of effectors, such as integrin alpha IIb, PAK1, and polo-like kinases, in different tissues. Recombinant human CIB1, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques