Fig 1: Effects of olmesartan administration on renal and lung ACE2 expression levels and plasma ACE2 activity. (A) Renal ACE2 protein expression levels and (C) mRNA expression levels in control, adenine, control-olmesartan, and adenine-olmesartan groups. (B) Pulmonary ACE2 protein expression levels and (D) mRNA expression levels in control, adenine, control-olmesartan, and adenine-olmesartan groups. (E) Plasma ACE2 activity in control, adenine, control-olmesartan, and adenine-olmesartan groups. Values are expressed as mean ± standard error of the mean (six mice per group). P values, versus control: *P < 0.05; **P < 0.01; ***P < 0.001. Olm, olmesartan.
Fig 2: Renal and pulmonary ACE2 expression levels and plasma ACE2 activity in aristolochic acid (AA)-induced CKD model mice. (A) Representative image of renal ACE2 immunostaining at 8 weeks after treatment in vehicle and AA groups. Bars = 50 µm. (B) Representative image of pulmonary ACE2 immunostaining at 8 weeks after treatment in vehicle and AA groups. Bars = 20 µm. (C) Renal ACE2 protein expression levels and (E) mRNA expression levels in vehicle and AA groups. (D) Pulmonary ACE2 protein expression levels and (F) mRNA expression levels in vehicle and AA groups. (G) Plasma ACE2 activity in vehicle and AA groups. Values are expressed as mean ± standard error of the mean (six mice per group). P values, versus vehicle: #P < 0.05; ##P < 0.01; ###P < 0.001. CKD, chronic kidney disease.
Fig 3: Renal and pulmonary ACE2 expression levels and plasma ACE2 activity in adenine-induced CKD mice. (A) Representative image of renal ACE2 immunostaining at 2 or 4 weeks after treatment in adenine and control groups. Bars = 50 µm. (B) Representative image of pulmonary ACE2 immunostaining at 2 or 4 weeks after treatment in adenine and control groups. Bars = 20 µm. (C) Renal ACE2 protein expression levels and (E) mRNA expression levels in adenine and control groups. (D) Pulmonary ACE2 protein expression levels and (F) mRNA expression levels in adenine and control groups. (G) Plasma ACE2 activity in adenine and control groups. Values are expressed as mean ± standard error of the mean (six mice per group). P values, versus control: *P < 0.05; **P < 0.01; ***P < 0.001.
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