Recombinant Human Lumican Protein, CF 2846-LU-050 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemRecombinant Human Lumican Protein, CF
CompanyR&D Systems, a Bio-Techne Brand
Price $449.00Supplier Page View Company Product Page
Catalog Number2846-LU-050
FormatLyophilized from a 0.2 µm filtered solution in PBS
SpeciesHuman
Size50 ug
Molecule NameLumican
ApplicationsBioactivity
Conjugate/TagUnconjugated
Source/Expression SystemNS0-derived Recombinant Human Lumican Protein, CF
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution
Molecular WeightObserved: 55-65 kDa, reducing conditions
Theoretical: 37.5 kDa
Purity>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining
NCBI Gene AliasesLDC, SLRR2D
NCBI Full Gene Namelumican

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Lumican Inhibits In Vivo Melanoma Metastasis by Altering Matrix-Effectors and Invadopodia MarkersCellsApril 8, 2021Karamanou K, Franchi M, Proult I, Rivet R, Vynios D, Brézillon S.Methods 2.1. Extracellular Matrix PROTEINS Recombinant human lumican (57 kDa) was purchased from R&D Systems (2846-LU050, R&D Systems, Minneapolis, MN, USA). Type I collagen was extracted from rat tail tendon, as previously

(2) Distinct effects of different matrix proteoglycans on collagen fibrillogenesis and cell-mediated collagen reorganizationScientific reportsNovember 4, 2020Chen D, Smith LR, Khandekar G, Patel P, Yu CK, Zhang K, Chen CS, Han L, Wells RG.

(3) Cleavage of proteoglycans, plasma proteins and the platelet-derived growth factor receptor in the hemorrhagic process induced by snake venom metalloproteinasesScientific reportsJuly 31, 2020Asega AF, Menezes MC, Trevisan-Silva D, Cajado-Carvalho D, Bertholim L, Oliveira AK, Zelanis A, Serrano SMT.

(4) Prolonged exposure to extracellular lumican restrains pancreatic adenocarcinoma growthOncogeneSeptember 21, 2017Li X, Kang Y, Roife D, Lee Y, Pratt M, Perez MR, Dai B, Koay EJ, Fleming JB.Sigma-Aldrich, St Louis, MO, USA) assay after lumican (recombinant human lumican protein CF, R&D Systems, 2846-LU-050, Minneapolis, MN, USA) treatment for 3 days. Primary PDAC cell lines MDA-PATC50, MDA-PATC53, MDA-PATC148

(5) Lumican effectively regulates the estrogen receptors-associated functional properties of breast cancer cells, expression of matrix effectors and epithelial-to-mesenchymal transitionScientific reportsMarch 23, 2017Karamanou K, Franchi M, Piperigkou Z, Perreau C, Maquart FX, Vynios DH, Brézillon S.affected. Materials and Methods Reagents Recombinant human lumican (57 kDa) was purchased from R&D Systems (#2846-LU-050, R&D Systems, MN, USA). Recombinant human pro-MMP-14 (catalytic domain, amino acids 89-265) was obtained

(6) Transforming Growth Factor-β Limits Secretion of Lumican by Activated Stellate Cells within Primary Pancreatic Adenocarcinoma TumorsClinical cancer research : an official journal of the American Association for Cancer ResearchOctober 1, 2016Kang Y, Roife D, Lee Y, Lv H, Suzuki R, Ling J, Rios Perez MV, Li X, Dai B, Pratt M, et al.

(7) Extracellular lumican augments cytotoxicity of chemotherapy in pancreatic ductal adenocarcinoma cells via autophagy inhibitionOncogeneSeptember 15, 2016Li X, Roife D, Kang Y, Dai B, Pratt M, Fleming JB.METHODS Reagents and cell lines Recombinant human lumican was purchased from R&D Systems (Minneapolis, MN, USA, 2846-LU-050). All other reagents were purchased from SigmaAldrich (St Louis, MO, USA), unless otherwise speciﬁed.

(8) Lumican Inhibits SNAIL-Induced Melanoma Cell Migration Specifically by Blocking MMP-14 ActivityPLOS ONEMarch 1, 2016Marta Stasiak et al.core protein (37 kDa) were produced as previously described [14, 18] or purchased from R&D Systems (#2846-LU-050, R&D Systems, MN, USA). Rabbit polyclonal anti-lumican antibody was produced as previously described

(9) Resistance of corneal RFUVA–cross-linked collagens and small leucine-rich proteoglycans to degradation by matrix metalloproteinasesInvestigative ophthalmology & visual scienceFebruary 5, 2013Zhang Y, Mao X, Schwend T, Littlechild S, Conrad GW.

(10) Lumican, an extracellular matrix proteoglycan, is a novel requisite for hepatic fibrosisLaboratory investigation; a journal of technical methods and pathologyDecember 1, 2012Krishnan A, Li X, Kao WY, Viker K, Butters K, Masuoka H, Knudsen B, Gores G, Charlton M.

(11) Lumican induces human corneal epithelial cell migration and integrin expression via ERK 1/2 signalingBiochemical and biophysical research communicationsJuly 18, 2008Seomun Y, Joo CK.

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Recombinant Human Lumican Protein, CF from R&D Systems, a Bio-Techne Brand

R&D Systems, a Bio-Techne Brand

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Recombinant Human Lumican Protein, CF from R&D Systems, a Bio-Techne Brand

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