Recombinant Mouse Ephrin-A1 Fc Chimera Protein, CF 602-A1-200 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemRecombinant Mouse Ephrin-A1 Fc Chimera Protein, CF
CompanyR&D Systems, a Bio-Techne Brand
Price $362.00Supplier Page View Company Product Page
Catalog Number602-A1-200
SpeciesMouse
Molecule NameEphrin-A1
Size200 ug
FormatLyophilized from a 0.2 µm filtered solution in PBS
NCBI Full Gene Nameephrin A1
NCBI Gene AliasesEfl1, Eplg1, B61, Lerk1, Epl1
Purity>90%, by SDS-PAGE under reducing conditions and visualized by silver stain
Molecular WeightObserved: 50-55 kDa, reducing conditions
Theoretical: 46.8 kDa (monomer)
ApplicationsBinding Activity
Conjugate/TagUnconjugated
Source/Expression SystemNS0-derived Recombinant Mouse Ephrin-A1 Fc Chimera Protein, CF
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Frequent EPHA2 receptor mutations in cholangiocarcinoma disrupt receptor forward signaling supporting a tumor suppressor roleBiochimica et Biophysica Acta (BBA) - Molecular Cell ResearchJanuary 1, 2026Evodie Koutouan, Alejandro Lillo, Ayano Kabashima, Jack W. Sample, Danielle Carlson, Rondell Graham, Rory L. Smoot, Elena B. PasqualeE9644), and antibiotics and antimycotics. For ligand stimulations, we used ephrinA1-Fc (R&D Systems, 602-A1–200) or equimolar Fc (MP Biomedicals, 0855911) as a control. The CGA-WLA-YR custom dimeric peptide purchased

(2) Frequent EPHA2 receptor mutations in cholangiocarcinoma disrupt receptor forward signaling supporting a tumor suppressor rolebioRxiv : the preprint server for biologyFebruary 28, 2025Koutouan E, Niibe A, Sample JW, Carlson D, Graham R, Smoot RL, Pasquale EB.

(3) Missense mutations of the ephrin receptor EPHA1 associated with Alzheimer's disease disrupt receptor signaling functionsThe Journal of biological chemistryFebruary 1, 2025Matsumoto M, Gomez-Soler M, Lombardi S, Lechtenberg BC, Pasquale EB.immunoprecipitation or immunoblotting. For ligand stimulation, cells were treated with ephrinA1-Fc (602-A1-200, R&D Systems/BioTechne; 2 μg/ml) for different time periods. To measure the half-life of EPHA1 WT or

(4) Transmembrane helix interactions regulate oligomerization of the receptor tyrosine kinase EphA2Journal of Biological ChemistryJuly 1, 2024Daniel Wirth, Ece Özdemir, William C. Wimley, Elena B. Pasquale, Kalina Hristovasupplemented with 200 nM monomeric EprhinA1 (Novoprotein, #CA70), 50 nM dimeric EphrinA1-Fc (R&D Systems, #602-A1-200), or 50 μM of the engineered peptide ligand YSA (YSAYPDSVPMMSGSGSK). The cells were allowed to equilibrate

(5) P-Y/G@NHs sensitizes non-small cell lung cancer cells to radiotherapy via blockage of the PI3K/AKT signaling pathwayBioorganic chemistryFebruary 1, 2023Zhang L, Zhou C, Zhou Y, Zhang W, Hu X, Chen M, Hui H, Guo L, Wu C, Zhou J, et al.

(6) Ligands with different dimeric configurations potently activate the EphA2 receptor and reveal its potential for biased signalingiScienceMarch 18, 2022Gomez-Soler M, Gehring MP, Lechtenberg BC, Zapata-Mercado E, Ruelos A, Matsumoto MW, Hristova K, Pasquale EB.treated for different times with saturating ligand concentrations: 50 nM ephrinA1-Fc (R&D Systems, #602-A1-200), 1,000 nM dimer (3), 100 nM dimer (7), 150 nM dimer (8) or 30 μM monomer (10). HEK293 cells stably

(7) EphA2 signaling within integrin adhesions regulates fibrillar adhesion elongation and fibronectin depositionMatrix biology : journal of the International Society for Matrix BiologySeptember 1, 2021Finney AC, Scott ML, Reeves KA, Wang D, Alfaidi M, Schwartz JC, Chitmon CM, Acosta CH, Murphy JM, Alexander JS, et al.media or serum-starved for 4 hours prior to stimulation with 1% FBS, 1 μg/mL fc-EphrinA1 (R&D Systems #602-A1-200), or 0.5 μM ALW-II-41-27 (a kind gift from Nathanael Grey, Harvard University) as indicated. EphA2

(8) Protein kinase C phosphorylates the EphA2 receptor on serine 892 in the regulatory linker connecting the kinase and SAM domainsCellular signallingSeptember 1, 2020Gehring MP, Pasquale EB.Alternatively, cells were treated with TPA for 10 min followed by 0.5 μg/ml ephrin-A1 Fc (R&D Systems, 602-A1–200) for an additional 20 min in the continued presence of TPA. In some cases cells were serum-starved before

(9) Matrix Rigidity Controls Epithelial-Mesenchymal Plasticity and Tumor Metastasis via a Mechanoresponsive EPHA2/LYN ComplexDevelopmental cellAugust 10, 2020Fattet L, Jung HY, Matsumoto MW, Aubol BE, Kumar A, Adams JA, Chen AC, Sah RL, Engler AJ, Pasquale EB, et al.Proteins" Recombinant active LYN,Sigma Aldrich,Cat#SRP5277 Recombinant ephrinA1-Fc,R&D Systems,Cat#602-A1–200 Bafetinib,Selleckchem,Cat#S1369 Nilotinib,Selleckchem,Cat#S1033 BI-D1870,Selleckchem,Cat#S2843 PP2,Selleckchem,Cat#S7008 VS-4718,Schlaepfer

(10) EphA2 contributes to disruption of the blood-brain barrier in cerebral malariaPLoS pathogensJanuary 1, 2020Darling TK, Mimche PN, Bray C, Umaru B, Brady LM, Stone C, Eboumbou Moukoko CE, Lane TE, Ayong LS, Lamb TJ.

(11) Structural and functional analyses reveal promiscuous and species specific use of ephrin receptors by Cedar virusProceedings of the National Academy of Sciences of the United States of AmericaOctober 8, 2019Laing ED, Navaratnarajah CK, Cheliout Da Silva S, Petzing SR, Xu Y, Sterling SL, Marsh GA, Wang LF, Amaya M, Nikolov DB, et al.

(12) Molecular and functional crosstalk between extracellular Hsp90 and ephrin A1 signalingOncotargetDecember 5, 2017Daoud A, Gopal U, Kaur J, Isaacs JS.within the context of EphA2 signaling and beyond. Reagents Recombinant Mouse Ephrin-A1/FC Chimera, (602A1-200, lot AOK1716012) and Recombinant Human IgG1-Fc (110-HG-100, lot EAX0616051) were purchased from R&D systems

(13) Protein kinase A can block EphA2 receptor-mediated cell repulsion by increasing EphA2 S897 phosphorylationMolecular biology of the cellSeptember 1, 2016Barquilla A, Lamberto I, Noberini R, Heynen-Genel S, Brill LM, Pasquale EB.3116964001) was from Roche Diagnostics (Indianapolis, IN). Recombinant proteins. Mouse ephrin-A1 Fc (602-A1-200) and recombinant human EGF (236-EG) were from R&D Systems (Minneapolis, MN); human Fc (ICN55911) was

(14) Phosphorylation of cyclin-dependent kinase 5 (Cdk5) at Tyr-15 is inhibited by Cdk5 activators and does not contribute to the activation of Cdk5The Journal of biological chemistryJuly 11, 2014Kobayashi H, Saito T, Sato K, Furusawa K, Hosokawa T, Tsutsumi K, Asada A, Kamada S, Ohshima T, Hisanaga S.

(15) ADAM12-cleaved ephrin-A1 contributes to lung metastasisOncogeneApril 24, 2014Ieguchi K, Tomita T, Omori T, Komatsu A, Deguchi A, Masuda J, Duffy SL, Coulthard MG, Boyd A, Maru Y.

(16) SLAP displays tumour suppressor functions in colorectal cancer via destabilization of the SRC substrate EPHA2Nature communicationsJanuary 1, 2014Naudin C, Sirvent A, Leroy C, Larive R, Simon V, Pannequin J, Bourgaux JF, Pierre J, Robert B, Hollande F, et al.NH4Cl (no. A9434) and Pepstatin A (no. P5318) were from Sigma Aldrich. Recombinant Ephrin-A1-Fc (no. 602-A1-200) was purchased from R&D Systems. Plasmids. The pcDNA3-SLAP-Flag, SLAP SH3*(P73L)-Flag, SLAP SH2*(R111E)Flag

(17) Using patterned supported lipid membranes to investigate the role of receptor organization in intercellular signalingNature protocolsApril 1, 2011Nair PM, Salaita K, Petit RS, Groves JT.PCI-3697-PI) Recombinant Streptavidin (Sigma-Aldrich, cat. no. S4762) Ephrin-A1 (R&D Systems, cat. no. 602-A1-200) ZEP-520A E-beam resist (Zeon Chemicals L.P.) Extra pure anisole (99%; Acros Organics, cat. no.

(18) Lithocholic acid is an Eph-ephrin ligand interfering with Eph-kinase activationPloS oneMarch 30, 2011Giorgio C, Hassan Mohamed I, Flammini L, Barocelli E, Incerti M, Lodola A, Tognolini M.

(19) Cooperative signaling between Slit2 and Ephrin-A1 regulates a balance between angiogenesis and angiostasisMolecular and cellular biologyFebruary 1, 2011Dunaway CM, Hwang Y, Lindsley CW, Cook RS, Wu JY, Boothby M, Chen J, Brantley-Sieders DM.

(20) Ligand targeting of EphA2 enhances keratinocyte adhesion and differentiation via desmoglein 1Molecular biology of the cellNovember 15, 2010Lin S, Gordon K, Kaplan N, Getsios S.

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Recombinant Mouse Ephrin-A1 Fc Chimera Protein, CF from R&D Systems, a Bio-Techne Brand

R&D Systems, a Bio-Techne Brand

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Recombinant Mouse Ephrin-A1 Fc Chimera Protein, CF from R&D Systems, a Bio-Techne Brand

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