PINK1 ELISA kits are immunoassay tools for the measurement of the protein PTEN induced kinase 1, which is encoded by the PINK1 gene in humans. Functionally, this protein is reported to be a serine/threonine-protein kinase, which protects against mitochondrial dysfunction during cellular stress by phosphorylating mitochondrial proteins such as PRKN and DNM1L, to coordinate mitochondrial quality control mechanisms that remove and replace dysfunctional mitochondrial components. The canonical protein structure is reported to have an amino acid length of 581 residues, a mass of 62.8 kDa, and is a member of the Ser/Thr protein kinase protein family. It is known to be localized in the mitochondria and cytoplasm and is reported to be highly expressed in heart, skeletal muscle and testis, and at lower levels in the brain, placenta, liver, kidney, pancreas, prostate, ovary and small intestine. As many as 2 protein isoforms have been reported. The protein has been noted to be post-translationally cleaved and phosphorylated. The PINK1 gene has been associated with the disease, Parkinson disease. Other alias names for this target include PTEN induced putative kinase 1, PTEN-induced putative kinase protein 1, protein kinase BRPK, and serine/threonine-protein kinase PINK1, mitochondrial.
There are PINK1 ELISA kits that can detect a target at concentrations as low as 0.156 ng/mL and as high as 20 ng/mL. Click on the products below for more detailed ELISA kit information, such as target reactivity and assay sensitivity.