CARD8 ELISA kits are immunoassay tools for the measurement of the protein caspase recruitment domain family member 8, which is encoded by the CARD8 gene in humans. Functionally, this protein is reported to be an inflammasome sensor, which mediates inflammasome activation in response to various pathogen-associated signals, leading to subsequent pyroptosis of CD4(+) T-cells and macrophages. The canonical protein structure is reported to have an amino acid sequence of 537 residues and a mass of 60.7 kDa. It is known to be localized in the nucleus and cytoplasm and is reported be highly expressed in the lung, ovary, testis and placenta. As many as 7 protein isoforms have been reported. The protein has been noted to be post-translationally ubiquitinated and cleaved. The CARD8 gene has been associated with the disease, Inflammatory bowel disease. Other alias names for this target include DACAR, DAKAR, NDPP, NDPP1, TUCAN, and CARDINAL.
The detection range for different CARD8 ELISA kits can vary, with some assays measuring target concentrations as low as 0.313 ng/mL and as high as 20 ng/mL. Click on the products below for more detailed ELISA kit information, such as target reactivity and assay sensitivity.