OTULIN ELISA kits are immunoassay tools for the measurement of the protein OTU deubiquitinase with linear linkage specificity, which is encoded by the OTULIN gene in humans. Functionally, this protein is a reported deubiquitinase that specifically removes linear ('Met-1'-linked) polyubiquitin chains to substrates and acts as a regulator of angiogenesis and innate immune response. The canonical protein structure is reported to have an amino acid length of 352 residues, a mass of 40.3 kDa, and is a member of the Peptidase C65 protein family. It is known to be localized in the cytoplasm. The protein has been noted to be post-translationally ubiquitinated, acetylated and phosphorylated. The OTULIN gene has been associated with the disease, Autoinflammation, panniculitis, and dermatosis syndrome. Other alias names for this target include OTU domain-containing deubiquitinase with linear linkage specificity, deubiquitinating enzyme otulin, family with sequence similarity 105, member B, and ubiquitin thioesterase otulin.
The detection range for different OTULIN ELISA kits can vary, with some assays measuring target concentrations as low as 0.156 ng/mL and as high as 10 ng/mL. Click on the products below for more detailed ELISA kit information, such as target reactivity and assay sensitivity.