SETD2 ELISA kits are immunoassay tools for the measurement of the protein SET domain containing 2, histone lysine methyltransferase, which is encoded by the SETD2 gene in humans. Functionally, this protein is a known histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate. The canonical protein structure is reported to have an amino acid length of 2564 residues, a mass of 287.6 kDa, and is a member of the Histone-lysine methyltransferase protein family. It is known to be localized in the nucleus and is ubiquitously expressed across many tissue types. As many as 3 protein isoforms have been reported. The protein has been noted to be post-translationally methylated. The SETD2 gene has been associated with the disease, Renal cell carcinoma. Other alias names for this target include HIF-1, HIP-1, HSPC069, HYPB, KMT3A, LLS, MRD70, and HBP231.
The detection range for different SETD2 ELISA kits can vary, with some assays measuring target concentrations as low as 0.156 ng/mL and as high as 20 ng/mL. Click on the products below for more detailed ELISA kit information, such as target reactivity and assay sensitivity.