Anti-TMCC2 antibodies are used in the immunodetection of the protein transmembrane and coiled-coil domain family 2. In humans, the canonical protein has a reported length of 709 amino acid residues and a mass of 77.4 kDa. Its subcellular localization is in the ER. Up to 4 different isoforms have been reported for this protein. It is notably widely expressed in many tissue types. A member of the TEX28 protein family, TMCC2 is suspected to be involved in the regulation of the proteolytic processing of the amyloid precursor protein (APP) possibly also implicating APOE. Synonyms for this target antigen include transmembrane and coiled-coil domains protein 2, cerebral protein 11, and HUCEP11. TMCC2 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Some TMCC2 antibodies may have been used in research and have associated citations. Western Blot is a widely used application for these antibodies. In addition, Immunohistochemistry is also a common application.