Anti-SIX3 antibodies are used in the immunodetection of the protein SIX homeobox 3. In humans, the canonical protein has a reported length of 332 amino acid residues and a mass of 35.5 kDa. Its subcellular localization is in the nucleus. A member of the SIX/Sine oculis homeobox protein family, SIX3 is a reported transcriptional regulator which can act as both a transcriptional repressor and activator by binding a ATTA homeodomain core recognition sequence on these target genes.
The SIX3 marker can be used to identify Brain Splatter Neurons.* Synonyms for this target antigen include homeobox protein SIX3, sine oculis homeobox homolog 3, sine oculis homeobox-like protein 3, and HPE2. SIX3 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. A number of SIX3 antibodies have been mentioned in research publications and have associated citations. Western Blot is a widely used application for these antibodies. In addition, ELISA is also a common application.
*HuBMAP Human Reference Atlas v1.4