Anti-PXK antibodies are used in the immunodetection of the protein PX domain containing serine/threonine kinase like. In humans, the canonical protein has a reported length of 578 amino acid residues and a mass of 65 kDa. Its subcellular localization is in the cell membrane and cytoplasm. Up to 7 different isoforms have been reported for this protein. It is found to be widely expressed in all tissues examined except in the heart. A member of the Protein kinase protein superfamily, PXK is known to bind to and modulates brain Na,K-ATPase subunits ATP1B1 and ATP1B3 and may thereby participate in the regulation of electrical excitability and synaptic transmission. Synonyms for this target antigen include SLOB, PX domain-containing protein kinase-like protein, PX ser/thr kinase v2, PX serine/threonine kinase, modulator of Na,K-ATPase long form, and MONAKA. PXK gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Western Blot is the most common application for the PXK antibodies listed below. ELISA and Immunohistochemistry are also common applications.