Anti-SPPL2C antibodies are used in the immunodetection of the protein signal peptide peptidase like 2C. In humans, the canonical protein has a reported length of 684 amino acid residues and a mass of 74.5 kDa. Its subcellular localization is in the ER. It is reported to be highly expressed in the testis where it is primarily localised in spermatids. A member of the Peptidase A22B protein family, SPPL2C is known to be involved with the regulation of intracellular calcium. Post-translational modifications have been described, including glycosylation. Synonyms for this target antigen include SPP-like 2C, intramembrane protease 5, and IMP-5. SPPL2C gene orthologs have been reported in the mouse, rat, bovine and chimpanzee species. Some SPPL2C antibodies may have been used in research and have associated citations. Western Blot is a widely used application for these antibodies. Immunocytochemistry and Immunofluorescence are also common applications.