Anti-SBS antibodies are protein reagents that detect specific antigens. The SBS antigen is another term for the human protein CYLD lysine 63 deubiquitinase, encoded by the CYLD gene. The protein is a reported deubiquitinase that specifically cleaves 'Lys-63'- and linear 'Met-1'-linked polyubiquitin chains and is involved in NF-kappa-B activation and TNF-alpha-induced necroptosis. Canonically, it has an amino acid length of 956 residues and a mass of 107.3 kilodaltons. Its subcellular localization is in the cell membrane and cytoplasm and it is notably expressed in fetal brain, testis, and skeletal muscle, and at a lower level in adult brain, leukocytes, liver, heart, kidney, spleen, ovary and lung. The SBS protein is a member of the Peptidase C19 protein family. Other alias names for SBS include BRSS, CDMT, and CYLD1. Western Blot is the most common application for the SBS antibodies listed below. ELISA and Immunohistochemistry are also common applications.