Anti-SEMA6B antibodies are used in the immunodetection of the protein semaphorin 6B. In humans, the canonical protein has a reported length of 888 amino acid residues and a mass of 95.3 kDa. Its subcellular localization is in the cell membrane. Up to 2 different isoforms have been reported for this protein. It is reported to be expressed in the brain in GABAergic neurons. A member of the Semaphorin protein family, SEMA6B is known to function as a cell surface repellent for mossy fibers of developping neurons in the hippocampus where it plays a role in axon guidance. Post-translational modifications have been described, including glycosylation. Synonyms for this target antigen include SEM-SEMA-Y, SEM-SEMA-Z, SEMA-VIB, SEMAN, semaZ, and EPM11. SEMA6B gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Some SEMA6B antibodies may have been used in research and have associated citations. Western Blot is a widely used application for these antibodies. In addition, ELISA is also a common application.