Anti-Shank antibodies are used in antigen-specific immunodetection in biological samples. The target Shank is a known alias name of the protein SH3 and multiple ankyrin repeat domains 2, encoded by the SHANK2 gene in humans. This 1849-amino acid residue protein is suspected to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. It is localized to the cell membrane and cytoplasm of the cell and features glycosylated post-translational modifications. It is reported to be expressed in many tissues, such as the caudate, vagina, and appendix. Other synonyms for Shank include AUTS17, CORTBP1, and CTTNBP1. Indicated applications for Shank antibodies listed below include ELISA, Western Blot, Immunocytochemistry, Immunofluorescence, Immunoprecipitation, and Immunohistochemistry.