Anti-Bruton Tyrosine Kinase antibodies are used for the immunodetection of the protein encoded by the BTK gene. In humans, the canonical protein has a reported length of 659 amino acid residues and a mass of 76.3 kDa. Its subcellular localization is in the cell membrane, nucleus, and cytoplasm. It is reported to be highly expressed in the B-lymphocytes. A member of the Tyr protein kinase protein family, it is a type of non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling. Post-translational modifications have been described, including phosphorylation. Other names for this target antigen include AT, ATK, BPK, IGHD3, IMD1, PSCTK1, XLA, and AGMX1. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Over 290 citations in the literature describe the use of Bruton Tyrosine Kinase antibodies in research. Western Blot is a widely used application for these antibodies. Immunofluorescence and Immunohistochemistry are also common applications.