Anti-SPRN antibodies are used in the immunodetection of the protein shadow of prion protein. In humans, the canonical protein has a reported length of 151 amino acid residues and a mass of 14.5 kDa. Its subcellular localization is in the cell membrane. It is reported to be mainly expressed in the brain. A member of the SPRN protein family, Sprn is reported to be a prion-like protein that has PrP(C)-like neuroprotective activity. Post-translational modifications have been described, including N-glycosylation. Synonyms for this target antigen include protein shadoo, shadow of prion protein homolog, and hypothetical protein BC004409. SPRN gene orthologs have been reported in the mouse, rat, bovine, zebrafish and chimpanzee species. Some Sprn antibodies may have been used in research and have associated citations. Western Blot, Immunofluorescence, and Immunohistochemistry are common applications for these antibodies.