Anti-TSPEAR antibodies are used in the immunodetection of the protein thrombospondin type laminin G domain and EAR repeats. In humans, the canonical protein has a reported length of 669 amino acid residues and a mass of 74.9 kDa. It has been described to be a secreted protein. Up to 2 different isoforms have been reported for this protein. TSPEAR is known to play an important role in tooth and hair follicle morphogenesis through regulation of the Notch signaling pathway. Post-translational modifications have been described, including glycosylation. Synonyms for this target antigen include DFNB98, ECTD14, STHAG10, thrombospondin-type laminin G domain and EAR repeat-containing protein, thrombospondin-type laminin G domain and EAR repeats-containing protein, and C21orf29. TSPEAR gene orthologs have been reported in the mouse, rat, bovine, frog, chimpanzee and chicken species. Some TSPEAR antibodies may have been used in research and have associated citations. ELISA, Western Blot, and Immunohistochemistry are common applications for these antibodies.