Anti-ADAMTS16 antibodies are used in the immunodetection of the protein ADAM metallopeptidase with thrombospondin type 1 motif 16. In humans, the canonical protein has a reported length of 1224 amino acid residues and a mass of 136.2 kDa. Its subcellular localization is in the extracellular matrix and is secreted. Up to 2 different isoforms have been reported for this protein. It is reported to be expressed in fetal lung and kidney and in adult prostate and ovary. ADAMTS16 is known to be involved with extracellular matrix organization and proteolysis. Post-translational modifications have been described, including N-glycosylation and protein cleavage.
The ADAMTS16 marker can be used to identify Deep-Layer Intratelencephalic Neurons.* Synonyms for this target antigen include a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 16, and A disintegrin and metalloproteinase with thrombospondin motifs 16. ADAMTS16 gene orthologs have been reported in the mouse, rat, bovine, frog and chimpanzee species.
*HuBMAP Human Reference Atlas v1.4