Anti-FBN2 antibodies are used in the immunodetection of the protein fibrillin 2. In humans, the canonical protein has a reported length of 2912 amino acid residues and a mass of 314.8 kDa. It has been described to be a secreted protein. Up to 2 different isoforms have been reported for this protein. It is notably expressed in the placenta. A member of the Fibrillin protein family, FBN2 is known to be involved with eye development and carbohydrate metabolism and homeostasis. Post-translational modifications have been described, including O-glycosylation and N-glycosylation.
The FBN2 marker can be used to identify Cerebral Cortex MGE Interneurons, Gray Matter MGE Interneurons, Brain Chandelier Neurons, and Gray Matter Chandelier Neurons.* Synonyms for this target antigen include DA9, EOMD, fibrillin 5, and CCA. FBN2 gene orthologs have been reported in the mouse, rat, bovine, frog, chimpanzee and chicken species. A number of FBN2 antibodies have been mentioned in research publications and have associated citations. ELISA is a widely used application for these antibodies. In addition, Western Blot is also a common application.
*HuBMAP Human Reference Atlas v1.4