Anti-NAGPA antibodies are used in the immunodetection of the protein N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase. In humans, the canonical protein has a reported length of 515 amino acid residues and a mass of 56.1 kDa. Its subcellular localization is in the Golgi. Up to 3 different isoforms have been reported for this protein. It is notably widely expressed in many tissue types. NAGPA is known to catalyze the second step in the formation of the mannose 6-phosphate targeting signal on lysosomal enzyme oligosaccharides by removing GlcNAc residues from GlcNAc-alpha-P-mannose moieties, which are formed in the first step. Synonyms for this target antigen include UCE, alpha-N-acetylglucosaminyl phosphodiesterase, lysosomal alpha-N-acetylglucosaminidase, mannose 6-phosphate-uncovering enzyme, phosphodiester alpha-GlcNAcase, and APAA. NAGPA gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Immunohistochemistry is the most common application for the NAGPA antibodies listed below. Immunocytochemistry and Immunofluorescence are also common applications.