Anti-myopalladin antibodies are used for the immunodetection of the protein encoded by the MYPN gene. In humans, the canonical protein has a reported length of 1320 amino acid residues and a mass of 145.3 kDa. Its subcellular localization is in the nucleus and cytoplasm. Alternative splicing is reported to yield 2 different isoforms for this protein. It is reported to be expressed in adult skeletal muscle and fetal heart. A member of the Myotilin/palladin protein family, it is a known component of the sarcomere that tethers together nebulin (skeletal muscle) and nebulette (cardiac muscle) to alpha-actinin, at the Z lines. The gene encoding this protein is implicated in Nemaline myopathy. Other names for this target antigen include sarcomeric protein myopalladin, 145 kDa (MYOP). Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Some myopalladin antibodies may have been used in research and have associated citations. These antibodies are most commonly used in Western Blot experiments, among other applications.