Anti-Apolipoprotein B antibodies are used for the immunodetection of the protein encoded by the APOB gene. In humans, the canonical protein has a reported length of 4563 amino acid residues and a mass of 515.6 kDa. Its subcellular localization is in the cytoplasm and is secreted. It is noted to be involved in TNF-mediated cellular signaling pathways and cholesterol metabolism and homeostasis. Post-translational modifications have been described, including palmitoylation and glycosylation. The gene encoding this protein is implicated in Hypobetalipoproteinemia. Other names for this target antigen include FLDB, LDLCQ4, apoB-100, apoB-48, apolipoprotein B-100, and FCHL2. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Over 140 citations in the literature describe the use of Apolipoprotein B antibodies in research. Western Blot is a widely used application for these antibodies. ELISA and Immunohistochemistry are also common applications.