Anti-ARRDC3 antibodies are used in the immunodetection of the protein arrestin domain containing 3. In humans, the canonical protein has a reported length of 414 amino acid residues and a mass of 46.4 kDa. Its subcellular localization is in the cell membrane, lysosomes and cytoplasm. It is reported to be highly expressed in skeletal muscle, placenta, kidney, lung, liver, blood, adrenal gland, lymph node, mammary gland, thyroid, and trachea. A member of a the Arrestin protein family, ARRDC3 is a reported adaptor protein that plays a role in regulating cell-surface expression of adrenergic receptors and probably also other G protein-coupled receptors. Synonyms for this target antigen include TBP-2-like inducible membrane protein, alpha-arrestin 3, and arrestin domain-containing protein 3.