Anti-ISL1 antibodies are used in the immunodetection of the protein ISL LIM homeobox 1. In humans, the canonical protein has a reported length of 349 amino acid residues and a mass of 39 kDa. Its subcellular localization is in the nucleus. It is reported to be expressed in subsets of neurons of the adrenal medulla and dorsal root ganglion, inner nuclear and ganglion cell layers in the retina, the pineal and some regions of the brain. ISL1 is known to be involved with neuronal development and the Wnt signaling pathway. Post-translational modifications have been described, including ubiquitination and phosphorylation.
The ISL1 marker can be used to identify Brain Medium Spiny Neurons, Amygdaloid Complex Medium Spiny Neurons, Brain Splatter Neurons, Hypothalamus Splatter Neurons, and Gray Matter Splatter Neurons.* Synonyms for this target antigen include insulin gene enhancer protein ISL-1, islet-1, and ISLET1. ISL1 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.
*HuBMAP Human Reference Atlas v1.4