Anti-PLTP antibodies are used in the immunodetection of the protein phospholipid transfer protein. In humans, the canonical protein has a reported length of 493 amino acid residues and a mass of 54.7 kDa. Its subcellular localization is in the nucleus and is secreted. Up to 4 different isoforms have been reported for this protein. It is widely expressed across many tissue types. A member of the BPI/LBP protein family, PLTP is known to mediate the transfer of phospholipids and free cholesterol from triglyceride-rich lipoproteins (low density lipoproteins or LDL and very low density lipoproteins or VLDL) into high-density lipoproteins (HDL) as well as the exchange of phospholipids between triglyceride-rich lipoproteins themselves.
The PLTP marker can be used to identify Cortical Thymic Epithelial Cells and Corticomedullary Thymic Epithelial Cells.* Synonyms for this target antigen include HDLCQ9, BPI fold containing family E, lipid transfer protein II, and BPIFE. PLTP gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. A number of PLTP antibodies have been mentioned in research publications and have associated citations. Western Blot is a widely used application for these antibodies. ELISA and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4