Anti-HLA-DOA antibodies are used in the immunodetection of the protein major histocompatibility complex, class II, DO alpha. In humans, the canonical protein has a reported length of 250 amino acid residues and a mass of 27.6 kDa. Its subcellular localization is in the endosome and lysosomes. It is notably expressed in many tissues, such as the lymph node and skeletal muscle. A member of the MHC class II protein family, HLA-DOA is known to be involved with adaptive immune responses and T cell differentiation. Post-translational modifications have been described, including glycosylation. Synonyms for this target antigen include HLA-DZA, HLADZ, HLA class II histocompatibility antigen, DO alpha chain, HLA-D0-alpha, MHC DN-alpha, and HLA-DNA. HLA-DOA gene orthologs have been reported in the mouse, rat and chimpanzee species. Some HLA-DOA antibodies may have been used in research and have associated citations. Western Blot is a widely used application for these antibodies. In addition, ELISA is also a common application.