Anti-DEF6 antibodies are used in the immunodetection of the protein DEF6 guanine nucleotide exchange factor. In humans, the canonical protein has a reported length of 631 amino acid residues and a mass of 73.9 kDa. Its subcellular localization is in the cell membrane, nucleus, and cytoplasm. It is notably expressed in the immune system. DEF6 is known to be involved with GPCR signaling pathways. Post-translational modifications have been described, including phosphorylation. The DEF6 gene has been associated with the disease, Immunodeficiency 87 and autoimmunity. Synonyms for this target antigen include IMD87, SLAT, SWAP70L, differentially expressed in FDCP 6 homolog, IRF4-binding protein, and IBP. DEF6 gene orthologs have been reported in the mouse, rat, bovine, frog, chimpanzee and chicken species. Some DEF6 antibodies may have been used in research and have associated citations. Western Blot is a widely used application for these antibodies. In addition, Immunohistochemistry is also a common application.