Anti-HLA-DPB1 antibodies are used in the immunodetection of the protein major histocompatibility complex, class II, DP beta 1. In humans, the canonical protein has a reported length of 258 amino acid residues and a mass of 29.2 kDa. Its subcellular localization is in the ER, Golgi, lysosomes, and cell membrane. It is notably widely expressed in many tissue types. A member of the MHC class II protein family, HLA-DPB1 is known to bind peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. Post-translational modifications have been described, including glycosylation.
The HLA-DPB1 marker can be used to identify Type 2 Dendritic (DC2) Cells and Blood Vessel Endothelial Cells.* Synonyms for this target antigen include HLA-DP, HLA-DP1B, HLA-DPB, HLA class II histocompatibility antigen, DP beta 1 chain, HLA class II histocompatibility antigen, DP(W4) beta chain, and DPB1. Over 240 citations in the literature describe the use of HLA-DPB1 antibodies in research. Flow Cytometry, Western Blot, Immunofluorescence, and Immunohistochemistry are common applications for these antibodies.
*HuBMAP Human Reference Atlas v1.4