Anti-EDNRA antibodies are used in the immunodetection of the protein endothelin receptor type A. In humans, the canonical protein has a reported length of 427 amino acid residues and a mass of 48.7 kDa. Its subcellular localization is in the cell membrane. Up to 5 different isoforms have been reported for this protein. A member of the G-protein coupled receptor 1 protein family, EDNRA is a known receptor for endothelin-1. Post-translational modifications have been described, including glycosylation.
The EDNRA marker can be used to identify Deep-Layer Corticothalamic And 6B Neurons, Cerebral Cortex MGE Interneurons, and Gray Matter CGE Interneurons.* Synonyms for this target antigen include ETA, ETA-R, ETAR, ETRA, MFDA, hET-AR, endothelin-1 receptor, and ET-A. EDNRA gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Over 90 citations in the literature describe the use of EDNRA antibodies in research. Western Blot, Immunofluorescence, and Immunohistochemistry are common applications for these antibodies.
*HuBMAP Human Reference Atlas v1.4