Anti-sprouty-related EVH1 domain containing 2 antibodies are used for the immunodetection of the protein encoded by the SPRED2 gene. In humans, the canonical protein has a reported length of 418 amino acid residues and a mass of 47.6 kDa. Its subcellular localization is in the cell membrane, cytoplasmic vesicles, and cytoplasm. Alternative splicing is reported to yield 2 different isoforms for this protein. It is reported to be expressed in the liver, skin, small intestine, salivary gland and prostate. It is noted to be involved in the regulation of cell differentiation and DNA damage pathways. Post-translational modifications have been described, including ubiquitination and phosphorylation. The gene encoding this protein is implicated in Noonan syndrome. Other names for this target antigen include sprouty protein with EVH-1 domain 2, related sequence, and sprouty-related, EVH1 domain-containing protein 2. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.