Anti-MDM4 regulator of p53 antibodies are used for the immunodetection of the protein encoded by the MDM4 gene. In humans, the canonical protein has a reported length of 490 amino acid residues and a mass of 54.9 kDa. Its subcellular localization is in the nucleus. Alternative splicing is reported to yield 5 different isoforms for this protein. It is reported to be expressed in all tissues tested with high levels in thymus. A member of the MDM2/MDM4 protein family, it is known to be involved with the cellular response to hypoxia and DNA damage pathways. Post-translational modifications have been described, including ubiquitination and phosphorylation. The gene encoding this protein is implicated in Bone marrow failure syndrome. Other names for this target antigen include HDMX, MDMX, MRP1, protein Mdm4, MDM4, p53 regulator, and BMFS6. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.