Anti-methyltransferase 1, tRNA methylguanosine antibodies are used for the immunodetection of the protein encoded by the METTL1 gene. In humans, the canonical protein has a reported length of 276 amino acid residues and a mass of 31.5 kDa. Its subcellular localization is in the nucleus. Alternative splicing is reported to yield 2 different isoforms for this protein. It is ubiquitously expressed across many tissue types. A member of the TrmB protein family, it is reported to be a catalytic component of METTL1-WDR4 methyltransferase complex that mediates the formation of N(7)-methylguanine in a subset of RNA species, such as tRNAs, mRNAs and microRNAs (miRNAs). Post-translational modifications have been described, including phosphorylation. Other names for this target antigen include TRM8, TRMT8, YDL201w, tRNA (guanine-N(7)-)-methyltransferase, D1075-like gene product, and C12orf1. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish and chimpanzee species.