Anti-activator of transcription and developmental regulator AUTS2 antibodies are used for the immunodetection of the protein encoded by the AUTS2 gene. In humans, the canonical protein has a reported length of 1259 amino acid residues and a mass of 139 kDa. Its subcellular localization is in the nucleus and cytoplasm. Alternative splicing is reported to yield 4 different isoforms for this protein. It is reported to be highly expressed in the brain, skeletal muscle and kidney. A member of the AUTS2 protein family, it is a known component of the Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. Other names for this target antigen include MRD26, autism susceptibility gene 2 protein, AUTS2, activator of transcription and developmental regulator, autism susceptibility candidate 2, autism-related protein 1, and FBRSL2. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.