Anti-osteoclastogenesis associated transmembrane protein 1 antibodies are used for the immunodetection of the protein encoded by the OSTM1 gene. In humans, the canonical protein has a reported length of 334 amino acid residues and a mass of 37.3 kDa. Its subcellular localization is in the lysosomes. A member of the OSTM1 protein family, it is known to be required for osteoclast and melanocyte maturation and function. Post-translational modifications have been described, including N-glycosylation and protein cleavage. The gene encoding this protein is implicated in Osteopetrosis. Other names for this target antigen include GL, OPTB5, osteopetrosis-associated transmembrane protein 1, CLCN7 accessory beta subunit, and GIPN. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.