Anti-sonic hedgehog signaling molecule antibodies are used for the immunodetection of the protein encoded by the SHH gene. In humans, the canonical protein has a reported length of 462 amino acid residues and a mass of 49.6 kDa. Its subcellular localization is in the ER, Golgi, cell membrane, and is secreted. A member of the Hedgehog protein family, it is known to be involved with T cell differentiation and the apoptotic pathway. Post-translational modifications have been described, including glycosylation, palmitoylation and protein cleavage. The gene encoding this protein is implicated in Microphthalmia. Other names for this target antigen include HHG1 and HLP3. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.