Anti-PTEN induced kinase 1 antibodies are used for the immunodetection of the protein encoded by the PINK1 gene. In humans, the canonical protein has a reported length of 581 amino acid residues and a mass of 62.8 kDa. Its subcellular localization is in the mitochondria and cytoplasm. Alternative splicing is reported to yield 2 different isoforms for this protein. It is reported to be highly expressed in the heart, skeletal muscle and testis, and at lower levels in the brain, placenta, liver, kidney, pancreas, prostate, ovary and small intestine. A member of the Ser/Thr protein kinase protein family, it is reported to be a serine/threonine-protein kinase, which protects against mitochondrial dysfunction during cellular stress by phosphorylating mitochondrial proteins such as PRKN and DNM1L, to coordinate mitochondrial quality control mechanisms that remove and replace dysfunctional mitochondrial components. Other names for this target antigen include PTEN induced putative kinase 1, PTEN-induced putative kinase protein 1, protein kinase BRPK, and serine/threonine-protein kinase PINK1, mitochondrial.