Anti-isoleucyl-tRNA synthetase 1 antibodies are used for the immunodetection of the protein encoded by the IARS1 gene. In humans, the canonical protein has a reported length of 1262 amino acid residues and a mass of 144.5 kDa. Its subcellular localization is in the cytoplasm. It is reported to be expressed in the liver and muscle. A member of the Class-I aminoacyl-tRNA synthetase protein family, it is known to catalyze the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. The gene encoding this protein is implicated in Growth retardation, impaired intellectual development, hypotonia, and hepatopathy. Other names for this target antigen include IARS, ILERS, ILRS, IRS, PRO0785, and GRIDHH. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.