Anti-notch receptor 3 antibodies are used for the immunodetection of the protein encoded by the NOTCH3 gene. In humans, the canonical protein has a reported length of 2321 amino acid residues and a mass of 243.6 kDa. Its subcellular localization is in the nucleus and cell membrane. It is widely expressed across many tissue types. A member of the NOTCH protein family, it is known to function as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Post-translational modifications have been described, including glycosylation, protein cleavage and phosphorylation. The gene encoding this protein is implicated in Cerebral arteriopathy. Other names for this target antigen include CADASIL1, CASIL, IMF2, LMNS, neurogenic locus notch homolog protein 3, Notch homolog 3, and CADASIL. Gene orthologs have been identified in the mouse, rat, bovine, frog and chimpanzee species.