Anti-thyroid stimulating hormone subunit beta antibodies are used for the immunodetection of the protein encoded by the TSHB gene. In humans, the canonical protein has a reported length of 138 amino acid residues and a mass of 15.6 kDa. It is known to be a secreted protein. Alternative splicing is reported to yield 2 different isoforms for this protein. A member of the Glycoprotein hormones subunit beta protein family, it is known to be important for the control of thyroid structure and metabolism. Post-translational modifications have been described, including glycosylation. The gene encoding this protein is implicated in Hypothyroidism. Other names for this target antigen include thyrotropin subunit beta, thyroid stimulating hormone beta, thyrotropin beta chain, and TSH-BETA. Gene orthologs have been identified in the mouse, rat, bovine, frog, chimpanzee and chicken species.