Anti-isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha antibodies are used for the immunodetection of the protein encoded by the IDH3A gene. In humans, the canonical protein has a reported length of 366 amino acid residues and a mass of 39.6 kDa. Its subcellular localization is in the mitochondria. Alternative splicing is reported to yield 2 different isoforms for this protein. A member of the Isocitrate and isopropylmalate dehydrogenases protein family, it is a known catalytic subunit of the enzyme which catalyzes the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The gene encoding this protein is implicated in Retinitis pigmentosa. Other names for this target antigen include isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial, H-IDH alpha, NAD(+)-specific ICDH subunit alpha, NAD(H)-specific isocitrate dehydrogenase alpha subunit, and RP90. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.