Anti-MAPK activated protein kinase 5 antibodies are used for the immunodetection of the protein encoded by the MAPKAPK5 gene. In humans, the canonical protein has a reported length of 473 amino acid residues and a mass of 54.2 kDa. Its subcellular localization is in the nucleus and cytoplasm. Alternative splicing is reported to yield 2 different isoforms for this protein. It is ubiquitously expressed across many tissue types. A member of the CAMK Ser/Thr protein kinase protein family, it is known to be involved with peptidyl-serine phosphorylation and protein phosphorylation. Post-translational modifications have been described, including phosphorylation. The gene encoding this protein is implicated in Neurocardiofaciodigital syndrome. Other names for this target antigen include MK5, NCFD, PRAK, MAP kinase-activated protein kinase 5, MAPKAP kinase 5, and MK-5. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.